MACLEAYA CORDATA EXTRACT AND SANGROVIT GENOTOXICITY. ASSESSMENT IN VIVO
نویسندگان
چکیده
منابع مشابه
Macleaya cordata extract and Sangrovit genotoxicity. Assessment in vivo.
BACKGROUND Sanguinarine (SG) has been reported to form DNA adducts in vitro and increase the levels of DNA single strand breaks in the blood and bone marrow of mice treated intraperitoneally with SG. Recently, we showed no genotoxic effects of orally administrated 120 mg/kg feed Macleaya cordata extract (a mixture of sanguinarine and chelerythrine) in pigs or rats in 90-day studies. The goal of...
متن کاملMacleaya cordata Extract Decreased Diarrhea Score and Enhanced Intestinal Barrier Function in Growing Piglets
Macleaya cordata extract is of great scientific and practical interest to researchers, due to its antimicrobial and anti-inflammatory responses within experimental animals. This study was designed to determine the diarrhea score and innate immunity of growing piglets after they had received Macleaya cordata extract supplements. A total of 240 growing pigs were randomly assigned to one of three ...
متن کاملMacleaya cordata Extract Reduces Inflammatory Responses of Intestinal Epithelial Cells in Vitro
Background: The EU ban on antimicrobial growth promoters (AGP) has initiated a search for nonantibiotic alternatives. It has been demonstrated that certain antibiotics and non-antibiotic alternatives enhance growth by inhibiting inflammatory cells, i.e. neutrophils and macrophages in the intestine. There is very little information on the effect of anti-inflammatory compounds on intestinal epith...
متن کاملGenotoxicity assessment of Elaeagnus angustifolia L. fruit extract (senjed) nanocapsule by in vitro and in vivo methods
Background: Although initial studies on Elaeagnus Angustifolia L. Fruit Extract (Senjed) Nanocapsule showed its efficacy in osteoporosis in rat model as well as its significant role in elevating the serum calcium levels, there is no study on its possible genotixic potentials which is necessary for developing all nanopharmaceuticals. Objective: This study aimed to evaluate the genotoxicity of Se...
متن کاملSafety assessment of sanguiritrin, alkaloid fraction of Macleaya cordata, in rats
The subchronic safety of sanguiritrin, a mixture of sanguinarine (SA) and chelerythrine (CHE) quaternary benzo[c]phenanthridine alkaloids (QBA), obtained from Macleaya cordata was assessed. Rats were fed a diet containing 120 ppm sanguiritrin (100 ppm QBA) for 109 days. The feed consumption and the animal weight were monitored. The content of QBA in selected tissues and plasma was determined us...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomedical Papers
سال: 2008
ISSN: 1213-8118,1804-7521
DOI: 10.5507/bp.2008.005